DSIP Peptide Research Guide 2026: Delta Sleep-Inducing Peptide Chemistry, COA and Handling

RESEARCH

Published September 11, 2026

DSIP Peptide Research Guide 2026: Delta Sleep‑Inducing Peptide Chemistry, COA and Handling

Compliance notice: DSIP is supplied strictly For Research Use Only — not for human consumption, not for veterinary use, not intended to diagnose, treat, cure, or prevent any disease. Nothing below is medical advice, no physiological outcome is claimed, and no dosing guidance is given or implied.

The DSIP peptide — delta sleep‑inducing peptide — is one of the older entries in the neuropeptide literature and one of the most frequently mis‑described. Most of what circulates about it online repeats a 1970s laboratory name rather than describing the molecule. This guide covers what DSIP is as a chemical entity: sequence, molecular weight, CAS number, how to verify a lot against a certificate of analysis, and how the material is handled.

Table of Contents

What DSIP Is

DSIP Chemistry at a Glance

What the Name Does and Does Not Tell You

Reading a DSIP Certificate of Analysis

Reconstitution, Solubility and Storage

Research FAQ

Sourcing DSIP for Research

What DSIP Is

DSIP is a short endogenous nonapeptide — nine amino acids — first isolated in 1974 by Schoenenberger and Monnier from the cerebral venous blood of rabbits. The name they assigned described the experimental model it was characterized in. It has followed the molecule for fifty years and is now its formal identifier in catalogs and databases, which is why you will see both DSIP and delta sleep‑inducing peptide on the same certificate.

Structurally it is unremarkable in the best sense: a small, linear, unmodified chain with no cyclization, no disulfide bridge and no terminal acetylation or amidation. That simplicity is why purity differences between suppliers come down to process control rather than to synthetic difficulty.

DSIP Chemistry at a Glance

These are the reference figures to check a vendor's documentation against. Confirm each on the lot‑specific certificate rather than trusting a product page, including ours.

Sequence: Trp‑Ala‑Gly‑Gly‑Asp‑Ala‑Ser‑Gly‑Glu, written in single‑letter code as WAGGDASGE.

Length: 9 amino acids (nonapeptide).

Molecular formula: C35H48N10O15.

Molecular weight: approximately 848.8 g/mol.

CAS number: 62568‑57‑4.

Appearance: white to off‑white lyophilized powder.

Two details matter practically. The single tryptophan at position one gives ultraviolet absorbance near 280 nm, which is what makes the peptide readable on a standard HPLC detector. The aspartic and glutamic acid residues make it acidic overall, which bears on solubility.

What the Name Does and Does Not Tell You

This is the part most write‑ups get wrong. "Delta sleep‑inducing peptide" is a historical laboratory designation from a specific 1974 rabbit model. It is nomenclature, not a specification, and not a description of any effect in humans. DSIP has no approved human use in the United States, and a compound name is never evidence of what a compound does. A vendor whose DSIP page argues from the name rather than from analytical data is telling you nothing verifiable.

Reading a DSIP Certificate of Analysis

A usable DSIP certificate carries a lot number matching the vial you received, a recent test date, and the name of the laboratory that ran the analysis. If any of those three is missing, the document is a marketing asset rather than an analytical one.

On the analysis itself, look for an HPLC chromatogram with a clearly integrated main peak and a stated purity percentage, plus a mass‑spectrometry confirmation. That mass figure is where DSIP is easy to check: the observed mass should correspond to roughly 848.8 g/mol for the free peptide. A result that does not reconcile with the stated sequence is a sequence problem, not a rounding problem. Our full method is in how to read a peptide COA, and the supplier‑vetting checklist is in how to verify peptide purity.

Reconstitution, Solubility and Storage

DSIP is readily soluble in water, making it one of the less troublesome peptides to bring into solution. Add diluent slowly down the inside wall of the vial and swirl gently. Do not shake, and do not direct the stream onto the powder cake.

Keep the lyophilized powder cold and shielded from light. Once reconstituted, keep it refrigerated and dark, and avoid repeated freeze‑thaw cycling — the most common avoidable cause of degradation in a short linear peptide. Vial strengths differ across the catalog, so the milligram figure on the label determines final concentration; run the arithmetic per lot. The step‑by‑step method is in how to reconstitute peptides, the diluent question is covered in bacteriostatic water vs sterile water, and general cold‑chain practice is in our peptide storage and handling guide.

Research FAQ

What is the DSIP peptide sequence?

DSIP is a nonapeptide with the sequence Trp‑Ala‑Gly‑Gly‑Asp‑Ala‑Ser‑Gly‑Glu, or WAGGDASGE in single‑letter code. It is linear and unmodified, with no disulfide bridge and no terminal modification.

What is the molecular weight and CAS number of DSIP?

DSIP is commonly listed at approximately 848.8 g/mol with the molecular formula C35H48N10O15, and its CAS number is 62568‑57‑4. Confirm the mass against the mass‑spectrometry figure on your lot‑specific certificate of analysis.

Where does the name delta sleep‑inducing peptide come from?

It is a historical laboratory designation assigned after the peptide was isolated from rabbit cerebral venous blood in 1974, reflecting the experimental model of that era. It is nomenclature only, not a claim about any effect in humans.

Is DSIP approved for human use?

No. DSIP has no approved human use in the United States. It is supplied For Research Use Only and is not for human consumption or veterinary use.

How should DSIP be stored?

Lyophilized powder cold and protected from light. Once reconstituted, refrigerated, light‑protected, and not repeatedly frozen and thawed. Never shake the vial.

Sourcing DSIP for Research

Because DSIP is a short unmodified chain, there is no synthetic difficulty to hide behind. What separates a usable lot from an unusable one is documentation you can check: a lot‑matched certificate, a real HPLC trace, a mass confirmation reconciling with the nine‑residue sequence, and a recent test date.

Precision Labs supplies DSIP 5mg and DSIP 10mg with lot‑matched third‑party analysis, and our testing process is documented on our lab testing page. If you want the current lot's certificate reviewed before you order, or have a specification question, contact our team — we will send the COA before you buy.

For Research Use Only. Not for human consumption. Not for veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.